Vanderbilt Hematologists Presenting at the 2019 ASH Annual Meeting

Vanderbilt University Medical Center researchers are excited to share insights with the hematology community at this year's gathering of the American Society of Hematology in Orlando.

At the ASH Annual Meeting & Exposition in Orlando this December 7-10, experts from Vanderbilt University Medical Center will share their insights on breaking topics from novel myeloid leukemia therapies to sickle cell disease trial outcomes.

Here’s where to find our presenters.

Saturday, Dec. 7

Session Type: Oral
Title: Developmental Plasticity of Acute Myeloid Leukemia Mediates Resistance to Venetoclax-Based Therapy
Contributors: Haley E. Ramsey, Ph.D., MSc; Michael R. Savona, M.D.; Stephen W. Fesik, Ph.D.
Location: Tangeine (WF3-4)
Time: 12:00 pm

Session Type: Oral
Title: The VITAL Trial: Phase II Trial of Vosaroxin and Infusional Cytarabine for Frontline Treatment of acute Myeloid Leukemia
Presenter: Stephen Strickland, M.D., MSCI, and Michael R. Savona, M.D.
Location: Chapin Theater (W320)
Time: 1:15 pm

Session Type: Oral
Title: Outcomes of Total Body Irradiation- Versus Chemotherapy-Based Myeloablative Conditioning Regimen in Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide for Acute Lymphoblastic Leukemia: ALWP of the EBMT Study
Presenter: Bhagirathbhai Dholaria, MBBS
Location: W307, Level 3
Time: 4:15 pm

Session Type: Poster
Title: JAK2V617F Clonal Hematopoiesis Stratifies By Peripheral Blood Counts
Presenter: Andrew Sochacki, M.D.
Location: Hall B
Time: 5:30 – 7:30 pm

Session Type: Poster
Title: Bone Marrow Morphologic Findings in Patients Receiving IDH Inhibitor Therapy in Combination with Intensive Induction Chemotherapy: Challenges with Interpretation of the Day 14 Bone Marrow Biopsy
Presenter: Emily F Mason, M.D., Ph.D.
Location: Hall B
Time: 5:30 – 7:30 pm

Session Type: Poster
Title: CUL1: Novel Therapeutic Target in Myeloid Neoplasms Harboring -7/Del(7q)
Presenter: Vera Adema, Ph.D.
Location: Hall B
Time: 5:30 pm – 7:30 pm

Session Type: Poster
Title: Oral Azacitidine and Cedazuridine Approximate Azacitidine Efficacy in a Murine Model
Presenter: Haley E. Ramsey, Ph.D., MSc
Location: Hall B
Time: 5:30 pm – 7:30 pm

Session Type: Poster
Title: Pevonedistat, a Nedd-8 Activating Enzyme Inhibitor, Upregulates NOXA to Increase Effectiveness of Azacitidine and Venetoclax in Preclinical Models of Acute Myelogenous Leukemia
Presenter: Brianna N Smith, M.D., MS
Location: Hall B
Time: 5:30 pm – 7:30 pm

Session Type: Poster
Title: Decline in Forced Expiratory Volume in 1 Second in Older Adults with Sickle Cell Disease Is Similar to Adults with Cystic Fibrosis
Presenter: Brock Hodges
Location: Hall B
Time: 5:30 pm – 7:30 pm

Session Type: Poster
Title: Impact of Novel Agents on Outcomes of Patients with Classical Hodgkin Lymphoma and Primary Treatment Failure
Author: Nishitha Reddy, M.D.
Location: Hall B
Time: 5:30 pm – 7:30 pm

Session Type: Poster
Title: Diagnostic Potential of Five Different Biomechanical Parameters to Detect Sclerotic Cutaneous Graft-Versus-Host Disease
Presenter: Fuyao Chen, BS
Location: Hall B
Time: 5:30 – 7:30 pm

Sunday, Dec. 8

Session Type: Oral
Title: The MAGIC Algorithm Probability (MAP): A Novel Laboratory Biomarker for the Response to Treatment of Acute Graft-Versus-Host Disease
Author: Carrie Kitko, MD1
Location: W230
Time: 7:30 am

Session Type: Poster
Title: Patient Specific Comorbidities Impact Overall Survival in Myelofibrosis
Presenter: Andrew Sochacki, M.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Nascent Transcript and Single Cell Rnaseq Analysis Defines the Mechanism of Action of the LSD1 Inhibitor INCB059872 in Myeloid Leukemia
Authors: Gretchen Johnston; Haley E. Ramsey, Ph.D., MSc; Kristy Stengel, Ph.D.; Scott Hiebert, Ph.D.; Michael R. Savona, M.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Variable Response to BCL2 Inhibition in MDS Is Enhanced across MDS Subtypes with Synergistic Combination of BCL2+MCL1 Inhibition
Authors: Melissa A. Fischer, MSc, Ph.D.; Maria Arrate, MSc; Merrida A Childress, Ph.D.;  Brianna N Smith, M.D., MS; Thomas Stricker, M.D., Ph.D.; Michael R. Savona, M.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Landmark Response and Survival Analyses from 102 MDS and CMML Patients Treated with Guadecitabine in a Phase 2 Study Showing That Maximum Response and Survival Is Best Achieved with Adequate Treatment Duration
Presenter: Michael R. Savona, M.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Overall Survival of Triple Class Refractory, Penta-Exposed Multiple Myeloma (MM) Patients Treated with Selinexor Plus Dexamethasone or Conventional Care: A Combined Analysis of the STORM and Mammoth Studies
Presenter: Luciano J. Costa, M.D., Ph.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Venetoclax-Based Salvage Therapy for Post-Hematopoietic Cell Transplantation Relapse in Acute Myeloid Leukemia (2 posters)
Authors: Nathalie Danielson, MSN; Adrianne Rasche, MSN; Rachel Hammers, MSN; Kathryn A Culos, PharmD; Katie S Gatwood, PharmD; Houston Wyatt, PharmD; Kristin Fogo, BSN; Bhagirathbhai Dholaria, MBBS; Brian G Engelhardt, M.D.; Paul Brent Ferrell Jr., M.D.; Madan Jagasia, MBBS, MS, MMHC; Adetola A. Kassim, M.D., MS; Sanjay R Mohan, M.D., MSCI; Bipin N. Savani, M.D.; Stephen A. Strickland, M.D.; Salyka M. Sengsayadeth, M.D.; Michael R. Savona, M.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Key Histopathology Features of Cutaneous Acute Graft-Versus-Host Disease Can be Detected Noninvasively
Presenter: Inga Saknite, Ph.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Stable Neurocognitive Function with Improvement in Processing Speed Following Haploidentical Bone Marrow Transplant with Post-Transplant Cytoxan in Children and Adolescents with Sickle Cell Disease
Authors: Kemar V Prussien; Karina L Wilkerson, NP, MSN; Adetola A. Kassim, M.D., MS
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Key Histopathology Features of Cutaneous Acute Graft-Versus-Host Disease Can be Detected Noninvasively
Authors: Jeffrey P Zwerner, M.D., Ph.D.; Heidi Chen, Ph.D.; Michael T Byrne, DO; Madan Jagasia, MBBS, MS, MMHC; Eric R. Tkaczyk, M.D., Ph.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Monday, Dec. 9

Session Type: Oral
Title: Primary Prevention of Strokes in Nigerian Children with Sickle Cell Disease (SPIN Trial): Final Results
Authors: Adetola A. Kassim, M.D., MS; Muktar Aliyu, M.D., MPH, DRPH; Michael R. DeBaun, M.D., MPH
Location: W304, ABCD
Time: 8:00 am

Session Type: Oral
Title: TP53 State Dictates Genome Stability, Clinical Presentation and Outcomes in Myelodysplastic Syndromes
Author: Michael R. Savona, M.D.
Location: W311, ABCD
Time: 11:00 am

Session Type: Oral
Title: Results of PAC203: A Randomized Phase 2 Dose-Finding Study and Determination of the Recommended Dose of Pacritinib
Author: Michael R. Savona, M.D.
Location: W311, EFGH
Time: 10:30 am

Session Type: Oral
Title: Reduced Intensity Conditioning for Haploidentical Bone Marrow Transplantation in Patients with Symptomatic Sickle Cell Disease: BMT CTN Protocol 1507
Presenter: Adetola A. Kassim, M.D., MS
Location: W311, EFGH
Time: 3:30 pm

Session Type: Oral
Title: Daratumumab, Carfilzomib, Lenalidomide and Dexamethasone (Dara-KRd) Induction, Autologous Transplantation and Post-Transplant, Response-Adapted, Measurable Residual Disease (MRD)-Based Dara-Krd Consolidation in Patients with Newly Diagnosed Multiple Myeloma (NDMM)
Author: Robert F. Cornell, M.D., MS
Location: Hall E2
Time: 4:45 pm

Session Type: Oral
Title: KD025 for Patients with Chronic Graft-Versus-Host Disease (cGVHD) – Long-Term Follow-up of a Phase 2a Study (KD025-208)
Presenter: Madan Jagasia, MBBS, MS, MMHC
Location: W230
Time: 4:45 pm

Session Type: Oral
Title: Pharmacokinetic Exposure Equivalence and Preliminary Efficacy and Safety from a Randomized Cross over Phase 3 Study (ASCERTAIN study) of an Oral Hypomethylating Agent ASTX727 (cedazuridine/decitabine) Compared to IV Decitabine
Author: Michael R. Savona, M.D.
Location: W311, ABCD
Time: 5:45 pm

Session Type: Poster
Title: Preliminary Results from a Phase II Study of the Combination of Pevonedistat and Azacitidine in the Treatment of MDS and MDS/MPN after Failure of DNA Methyltransferase Inhibition
Authors: Run Fan, Ph.D., MS; Ingrid A Anderson, Ph.D.; Andrew Sochacki, M.D.; Stephen A. Strickland, M.D.; Michael T Byrne, D.O.; Sanjay R Mohan, M.D., MSCI; Michael R. Savona, M.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Abnl Marro: An International Cooperative Trial for Patients with MDS/MPN Overlap Syndromes
Presenter: Michael R. Savona, M.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Outcomes of Total Body Irradiation- Versus Chemotherapy-Based Myeloablative Conditioning Regimen in Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide for Acute Myelogenous Leukemia: ALWP of the EBMT Study
Author: Bipin N. Savani, M.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Landmark Response and Survival Analyses from 206 AML Patients Treated with Guadecitabine in a Phase 2 Study Demonstrate the Importance of Adequate Treatment Duration to Maximize Response and Survival Benefit. Survival Benefit Not Restricted to Patients with Objective Response
Contributor: Michael R. Savona, M.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Diagnostic Testing Patterns and Concordance with World Health Organization (WHO) Criteria for Patients (Pts) with Newly Diagnosed (ND) Myelodysplastic Syndromes (MDS) in the Connect® MDS/AML Registry
Contributor: Michael R. Savona, M.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Geno-Clinical Model for the Diagnosis of Bone Marrow Myeloid Neoplasms
Authors: Michael R. Savona, M.D.; Brianna N Smith, M.D., MS
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Noninvasive Microscopic Imaging Reveals Increased Leukocyte Adhesion and Rolling in Skin of Acute Graft-Versus-Host Disease Patients Compared to Post-Transplant Controls
Authors: Michael T Byrne, D.O.; Madan Jagasia, MBBS, MS, MMHC; Heidi Chen, Ph.D.; Eric R. Tkaczyk, M.D., Ph.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Transfusion Support in Patients with Sickle Cell Anemia Undergoing Haploidentical Hematopoietic Cell Transplantation
Presenter: Jennifer Andrews, M.D., MSc
Authors: Dilan A Patel, M.D.; Deva Sharma, M.D., MS; Adetola A. Kassim, M.D., MS
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Sickle Cell Disease Post-Transplant Care Challenges in Nigeria: Systematic Institutional Neglect of Medical Tourism
Author: Adetola A. Kassim, M.D., MS; Michael R. DeBaun, M.D., MPH
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Combination of Nivolumab, Lenalidomide and Rituximab in Relapsed/Refractory Non-Germinal Center Diffuse Large B Cell Lymphoma: Results from a Dose-Escalation Cohort
Presenter: Tarsheen Sethi, M.D., MBBS
Authors: Alexandra E. Kovach, M.D., Emily F Mason, M.D., Ph.D., Heidi Chen, Ph.D., Tamara Moyo, M.D., Ph.D., Olalekan O. Oluwole, MBBS, MPH, David Morgan, M.D.; Nishitha Reddy, M.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Next Generation Sequence Minimal Residual Disease (NGS-MRD) Predicts Outstanding Event Free Survival (EFS) Regardless of Hematopoietic Cell Transplantation (HCT) Preparative Approach or Graft Alpha/Beta Depletion in Children with Acute Lymphoblastic Leukemia (ALL)
Author: Carrie Kitko, M.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Efficacy of Methoxsalen Sterile Solution in Conjunction with the Therakos® Cellex® Photopheresis System in Pediatric Patients with Steroid-Refractory Acute GvHD: Interim Analysis
Presenter: Carrie Kitko, M.D.
Location: Hall B
Time: 6:00 – 8:00 pm

Session Type: Poster
Title: Interobserver Reproducibility of the Myoton and Durometer Devices to Measure Skin Stiffness and Hardness in Chronic Cutaneous Graft-Versus-Host Disease Patients
Presenter: Laura Wang, BS
Authors: Fuyao Chen, BS; Heidi Chen, Ph.D.; Madan Jagasia, MBBS, MS, MMHC; Eric R. Tkaczyk, M.D., Ph.D.
Location: Hall B
Time: 6:00 – 8:00 pm